Obesity is associated with greater cognitive function in patients with type 2 diabetes mellitus

• DOI: 10.3389/fendo.2022.953826
• Publication Date: 2022-10-24T07:08:09Z
• Authors: Zhenhua Xing; Chen Long; Xinqun Hu; Xiangping Chai
• Keywords: Stroop effect; Trail Making Test

Background The impact of obesity on cognitive function in patients with type 2 diabetes mellitus (T2DM) remains controversial. This study aimed to evaluate whether obesity, assessed by body mass index (BMI) was associated among T2DM and the effect through brain structure. Methods a post-hoc analysis Action Control Cardiovascular Risk Diabetes–Memory Diabetes (ACCORD-MIND) study. test battery included Digit Symbol Substitution Test (DSST), Mini-Mental State Exam (MMSE), Rey Auditory Verbal Learning (RAVLT), STROOP test, which were administered at baseline, 20, 40, 80 months. A subgroup (n = 614) ACCORD-MIND underwent MRI scanning baseline 40 total volume (TBV), abnormal white matter (AWM), gray (AGM), basal ganglia (ABG) estimated. outcomes this Results In adjusted analyses, BMI positively MMSE (β:0.08, 95%CI,0.01-0.16, per standard deviation [SD] increase) RAVLT scores (β:0.09, 95%CI,0.01-0.18). It also greater TBV (β:7.48, 95%CI,0.29-14.67). not DSST or scores, AWM, AGM, ABG. Mediation found that MMSE/RAVLT mediated TBV. Conclusion Obesity may be T2DM. Clinical Trial Registration http://www.clinicaltrials.gov , identifier NCT00000620.