Glycemic variability evaluated by HbA1c rather than fasting plasma glucose is associated with adverse cardiovascular events

• DOI: 10.3389/fendo.2024.1323571
• Publication Date: 2024-02-14T04:17:57Z
• Authors: Lijuan Sheng; Guifang Yang; Xiangping Chai; Yang Zhou; Xin Sun; Zhenhua Xing
• Keywords: Quartile

Background Although studies have shown that glycemic variability is positively associated with an increased risk of cardiovascular disease, few compared hemoglobin A1c (HbA1c) and fasting plasma glucose (FPG) adverse events in patients type 2 diabetes mellitus (T2DM). Methods This was a post hoc analysis the Action to Control Cardiovascular Risk Diabetes (ACCORD) study. Cox proportional hazards models were used explore relationship between HbA1c or FPG incidence major (MACEs). Results In total, 9,547 T2DM enrolled this During median 4.6 ± 1.5 years follow-up period, 907 developed MACEs. The MACEs group each higher quartile (P < 0.01). Compared those first variability, fourth had hazard ratio 1.37 (Model 2, 95% confidence interval: 1.13–1.67) for Higher not trend=0.28). A U-shaped observed Glucose control therapy modified MACEs; participants receiving intensive more likely develop interaction <0.01). Conclusion adults T2DM, evaluated using U-shaped, increase rather than significantly affected by strategy, strongly strategy.