Impact of stress hyperglycemia ratio on mortality in patients with cardiac arrest: insight from American MIMIC-IV database

• DOI: 10.3389/fendo.2024.1383993
• Publication Date: 2024-05-21T04:41:01Z
• Authors: Li-You Lian; Wei-Hao Xue; Jia-Jia Lu; Ru-Jie Zheng
• Keywords: Male; diabetes; Databases, Factual; cardiac arrest; Middle Aged; RC648-665; Prognosis; mortality; Diseases of the endocrine glands. Clinical endocrinology; United States; Heart Arrest; Intensive Care Units; 03 medical and health sciences; Endocrinology; 0302 clinical medicine; Hyperglycemia; stress hyperglycemia ratio; Humans; Female; prognosis; Aged

Background Stress hyperglycemia ratio (SHR) has shown a predominant correlation with transient adverse events in critically ill patients. However, there remains gap comprehensive research regarding the association between SHR and mortality among patients experiencing cardiac arrest admitted to intensive care unit (ICU). Methods A total of 535 their initial ICU admission suffered arrest, according American Medical Information Mart for Intensive Care (MIMIC)-IV database. Patients were stratified into four categories based on quantiles SHR. Multivariable Cox regression models used evaluate mortality. The was assessed using multivariable models. Subgroup analyses conducted determine whether influenced ICU, 1-year, long-term all-cause subgroups diabetes status. Results higher SHR, when compared reference quartile 1 group, exhibited greater risk (adjusted hazard [aHR] = 3.029; 95% CI: 1.802-5.090), 1-year (aHR 3.057; 1.885-4.958), 3.183; 2.020-5.015). This particularly noteworthy without diabetes, as indicated by subgroup analysis. Conclusion Elevated notably associated heightened risks These findings underscore importance considering potential prognostic factor critical management patients, warranting further investigation clinical attention.