Gut microbiota profiling reflects the renal dysfunction and psychological distress in patients with diabetic kidney disease

• DOI: 10.3389/fendo.2024.1410295
• Publication Date: 2024-07-15T04:23:32Z
• Authors: Qi Li; Suyi Xie; Yali Liu; Wei Yue; Limin Wang; Yi Liang; Yan Chen; Huijuan Yuan; Jiawei Yu
• Keywords: Roseburia

Background The gut microbiota plays a pivotal role in the development of diabetes and kidney disease. However, it is not clear how intestinal microecological imbalance involved context diabetic disease (DKD), leading cause renal failure. Objectives To elucidate microbial signatures associated with DKD progression towards end-stage (ESRD) explore whether they could reflect dysfunction psychological distress. Methods A cross-sectional study was conducted to 29 non-ESRD patients 19 ESRD compared 20 healthy controls. Differential analysis performed detect distinct alterations diversities taxon abundance without ESRD. Renal estimated by urea, creatinine, glomerular filtration rate. Psychological distress assessed using Self-Rating Anxiety Scale, Depression Hamilton Rating Scale. Results Alpha diversity indexes were reduced patients, particularly those Beta revealed that compositions different individuals whereas similar observed patients. Taxon differential showed when controls, exhibit profiles including abundances butyrate-produced, anti-inflammatory bacteria Faecalibacterium , Lachnospira Roseburia Lachnoclostridium increased pro-inflammatory Collinsella Streptococcus etc. These distinctive genera presented consistent associations dysfunction, as well distress, especially Conclusions who have progressed ESRD, unique characteristics their are both may be significant factor deterioration its eventual