No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: A Mendelian Randomization Analysis

• DOI: 10.3389/fgene.2021.569323
• Publication Date: 2021-02-20T21:31:47Z
• Authors: Josephine Mensah-...; Amand F. Schmidt; Aroon D. Hingorani; Chris Finan; Yutang Chen; Stefan van Duijve...; Michele Orini; Pier D. Lambiase; Andrew Tinker; Eirini Marouli; Patricia B. Munroe; Julia Ramírez
• Keywords: Mendelian Randomization; Stroke; Genome-wide Association Study

Reduced heart rate (HR) increase (HRI), recovery (HRR), and higher resting HR are associated with cardiovascular (CV) disease, but causal inferences have not been deduced. We investigated effects of HRI, HRR, on CV risk, all-cause mortality (ACM), atrial fibrillation (AF), coronary artery disease (CAD), ischemic stroke (IS) using Mendelian Randomization.11 variants for 11 two sets 46 414 were obtained from four genome-wide association studies (GWASs) UK Biobank. performed a lookup GWASs risk ACM in Biobank (N = 375,367, 5.4% cases N 393,165, 4.4% cases, respectively). For CAD, AF, IS, we used publicly available summary statistics. random-effects inverse-variance weighted (IVW) method sensitivity analyses to estimate causality.IVW showed nominally significant effect HRI events (odds ratio [OR] 1.0012, P 4.11 × 10-2) CAD AF. Regarding IVW was any outcome. The indicated statistically associations AF (OR 0.9825, 9.8 10-6), supported by all analyses, IS 0.9926, 9.82 10-3).Our findings suggest no strong evidence an between HRR outcome confirm prior work reporting highly Future research is required explore further more powerful predictors, when available.