Identification of the Functions and Prognostic Values of RNA Binding Proteins in Bladder Cancer

• DOI: 10.3389/fgene.2021.574196
• Publication Date: 2021-06-22T05:48:46Z
• Authors: Yue Wu; Zheng Liu; Xian Wei; Huan Feng; Bintao Hu; Bo Liu; Yang Luan; Yajun Ruan; Xiaming Liu; Zhuo Liu; Shaogang Wang; Jihong Liu; Tao Wang
• Keywords: Nomogram

Post-transcriptional regulation plays a leading role in gene and RNA binding proteins (RBPs) are the most important posttranscriptional regulatory protein. RBPs had been found to be abnormally expressed variety of tumors is closely related its occurrence progression. However, exact mechanism bladder cancer (BC) unknown. We downloaded transcriptomic data BC from Cancer Genome Atlas (TCGA) database used bioinformatics techniques for subsequent analysis. A total 116 differentially were selected, among which 61 up-regulated 55 down-regulated. then identified 12 prognostic including CTIF, CTU1, DARS2, ENOX1, IGF2BP2, LIN28A, MTG1, NOVA1, PPARGC1B, RBMS3, TDRD1 , ZNF106 constructed risk score model. Based on this model we that patients high-risk group poorer overall survival ( P < 0.001), area under receiver operator characteristic curve was 0.677 1 year, 0.697 3 years, 0.709 5 years. Next, drew nomogram based other clinical variables, showed better predictive performance. Our findings contribute understanding pathogenesis, progression metastasis BC. The these genes has good value may have prospects improving treatment regimens patient prognosis.