m6A RNA Methylation Regulators Act as Potential Prognostic Biomarkers in Lung Adenocarcinoma

• DOI: 10.3389/fgene.2021.622233
• Publication Date: 2021-02-10T17:44:24Z
• Authors: Hongbo Wang; Xiangxuan Zhao; Zaiming Lu
• Keywords: RNA methylation; Heterogeneous nuclear ribonucleoprotein; Transcription

N 6 -methyladenosine [m(6)A/m A] methylation is one of the most common RNA modifications in eukaryotic cell mRNA and plays an important regulatory role metabolism, splicing, translocation, stability, translation. Previous studies have demonstrated that m A modification highly associated with tumor proliferation, migration, invasion. In present study, five factors been revealed, namely heterogeneous nuclear ribonucleoprotein A2/B1(HNRNPA2B1), C (HNRNPC), Vir like methyltransferase protein (KIAA1429/VIRMA), binding motif 15 (RBM15) 3 (METTL3), which are closely related to overall survival (OS) patients lung adenocarcinoma (LUAD). These exhibited potential prognostic value for 1, 3, 5-years outcomes LUAD patients. Our findings revealed several signaling pathways, such as cycle, DNA replication, degradation, polymerase, nucleotide excision repair basal transcription factors, activated high-risk group