A Missense Mutation in the MYBPH Gene Is Associated With Abdominal Fat Traits in Meat-Type Chickens

• DOI: 10.3389/fgene.2021.698163
• Publication Date: 2021-08-11T09:07:02Z
• Authors: Priscila Anchieta...; Gabriel Costa Mon...; Clarissa Boschiero; Aline Silva Mello...; Juliana Petrini; Gabriel Rodrigues...; Mônica Corrêa Ledur; Gerson Barreto Mo...; Dorian Garrick; Luiz Lehmann Cout...
• Keywords: Genome-wide Association Study; Genetic Association; SNP; Candidate gene; Genetic architecture

Chicken is an important source of protein for human nutrition and a model system growth developmental biology. Although the genetic architecture quantitative traits in meat-type chickens has been subject ongoing investigation, identification mutations associated with carcass economic interest remains challenging. Therefore, our aim was to identify predicted deleterious mutation, which potentially affects function, test if they were chickens. For that, we performed genome-wide association analysis (GWAS) breast, thigh drumstick detected 19 unique trait loci (QTL). We then used: (1) identified windows; (2) QTL abdominal fat previous study same population (3) previously obtained whole genome sequence data, 18 single nucleotide polymorphisms (SNPs) those further thigh, traits. Using additive model, SNP c.482C > T (SIFT score 0.4) ( p-value < 0.05) weight percentage. This second exon MYBPH gene, its allele frequency deviates from Hardy–Weinberg equilibrium. In conclusion, provides evidence that gene putative causal mutation deposition