A Ferroptosis-Related Prognostic Signature Based on Antitumor Immunity and Tumor Protein p53 Mutation Exploration for Guiding Treatment in Patients With Head and Neck Squamous Cell Carcinoma

• DOI: 10.3389/fgene.2021.732211
• Publication Date: 2021-09-20T06:33:37Z
• Authors: Xin Fan; YangShaobo Ou; Huijie Liu; Liangzhen Zhan; Xingrong Zhu; Mingyang Cheng; Qun Li; Dongmei Yin; Lan Liao
• Keywords: Nomogram

Background: Due to the lack of accurate guidance biomarkers, treatment head and neck squamous cell carcinoma (HNSCC) has not been ideal. Ferroptosis plays an important role in tumor suppression patients. However, protein p53 (TP53) mutation may promote progression through ferroptosis. Therefore, it is particularly mine prognostic-related differentially expressed ferroptosis-related genes (PR-DE-FRGs) HNSCC construct a prognostic model for accurately guiding clinical treatment. Methods: First, data obtained from The Cancer Genome Atlas (TCGA) was used identify PR-DE-FRGs screening candidate model. We only variety methods verify accuracy predicting prognosis but also explored ferroptosis development perspective immune microenvironment mutation. Finally, we correlation between drew high-precision nomogram predict prognosis. Results: Seventeen 29 were selected with good predictive performance. Patients low-risk group found have greater number CD8 + T cells, follicular helper regulatory mast T-cell costimulations, type II interferon responses. A higher burden (TMB) observed associated better risk score TP53 worse closely related expression checkpoint inhibitors (ICIs)-related such as PD-L1 IC50 six chemotherapeutic drugs. constructed performs well Conclusion: participate built can be effective predictor immunotherapy chemotherapy effects