Protumorigenic Role of Elevated Levels of DNA Polymerase Epsilon Predicts an Immune-Suppressive Microenvironment in Clear Cell Renal Cell Carcinoma

• DOI: 10.3389/fgene.2021.751977
• Publication Date: 2021-12-07T13:33:46Z
• Authors: Xiaohui Wu; Haijia Tang; Wen-Hao Xu; Haidan Tang; Shiyin Wei; Aihetaimujiang An...; Haineng Huang; Yuan-Yuan Qu; Hailiang Zhang; Shuai Zhao; Hui Li; Wangrui Liu; Hongjing Chen; Chen Ding; Dingwei Ye
• Keywords: Immune checkpoint

Increasing evidence indicates that DNA polymerase epsilon (POLE), which mediates damage repair, is significantly associated with tumor prognosis. This study aimed to analyze POLE expression in samples and its prognostic value for patients clear cell renal carcinoma (ccRCC). We found elevated ccRCC tissues compared normal of multiple independent cohorts. The levels 523 (The Cancer Genome Atlas RNA-seq data) 179 immunohistochemical data (Fudan University Shanghai Center) were analyzed investigate the implications expression. Cox regression analyses implemented explore effect on prognosis pan-cancer. These findings revealed correlated shorter overall survival (p < 0.001, n = 701) ccRCC. indicate may serve as a biomarker cancers. Although mutations not benefits conferred upon ccRCC, CD4+ T cell-regulated immune microenvironment was activated. Moreover, we cancers an immunosuppressive microenvironment, higher intratumoral heterogeneity, checkpoint genes PDCD1, CTLA4, CD86, possibly mediated via JAK/STAT Notch signaling pathways. In conclusion, present first our knowledge poor immune-suppressive suggest can guiding molecular diagnosis facilitating development novel individual therapeutic strategies advanced