Multigenomics Reveals the Causal Effect of Herpes Simplex Virus in Alzheimer’s Disease: A Two-Sample Mendelian Randomization Study

• DOI: 10.3389/fgene.2021.773725
• Publication Date: 2022-01-05T06:03:58Z
• Authors: Yuwei Zhang; Jiaojiao Qu; Li Luo; Zhongshun Xu; Xiao Zou
• Keywords: Mendelian Randomization

In recent years, the herpes virus infectious hypothesis for Alzheimer's disease (AD) has gained support from an increasing number of researchers. Herpes simplex (HSV) is a potential risk factor associated with AD. This study assessed whether HSV causal relationship AD using two-sample Mendelian randomization analysis model. Six single-nucleotide polymorphisms (SNPs) HSV-1 and thirteen SNPs HSV-2 were used as instrumental variables in MR analysis. We estimated values relevance between exposure inverse-variance weighted (IVW) method, MR-Egger regression (Egger), median estimator (WME). To make conclusion more robust reliable, sensitivity analyses RadialMR performed to evaluate pleiotropy heterogeneity. found that anti-HSV-1 IgG measurements not (OR, 0.96; 95% CI, 0.79-1.18; p = 0.736), same was true 1.03; 0.94-1.12; 0.533). The findings indicated any infection does appear be genetically valid target intervention