The Impact of ACEs on BMI: An Investigation of the Genotype-Environment Effects of BMI

• DOI: 10.3389/fgene.2022.816660
• Publication Date: 2022-03-07T10:00:01Z
• Authors: Karen A. Schlauch; Robert W. Read; Iva Neveux; Bruce Lipp; Anthony Slonim; Joseph J. Grzymski
• Keywords: Affect

Adverse Childhood Experiences are stressful and traumatic events occurring before the age of eighteen shown to cause mental physical health problems, including increased risk obesity. Obesity remains an ongoing national challenge with no predicted solution. We examine a subset Healthy Nevada Project, focusing on multi-ethnic cohort 15,886 sequenced participants recalled adverse childhood events, study how ACEs their genotype-environment interactions affect BMI. Specifically, Project by Helix Exome+ platform were cross-referenced electronic medical records social determinants questionnaire identify: 1) effect BMI in absence genetics; 2) BMI; 3) these gene-environment differ from standard genetic associations The found very strong significant between number experiences adult Additionally, we identified fifty-five common rare variants that exhibited gene-interaction effects three CAMK1D gene four LHPP; both genes linked schizophrenia. Surprisingly, none interactive canonical obesity-related genes. Here show delicate balance environment, two strongly influence each other.