The GNB3 c.825C>T (rs5443) polymorphism and protection against fatal outcome of corona virus disease 2019 (COVID-19)

• DOI: 10.3389/fgene.2022.960731
• Publication Date: 2022-08-09T04:34:00Z
• Authors: Birte Möhlendick; Kristina Schönfelder; Christoph Zacher; Carina Elsner; Hana Rohn; Margarethe J. Konik; Laura Thümmler; Vera Rebmann; Monika Lindemann; Karl-Heinz Jöckel; Winfried Siffert
• Keywords: 2019-20 coronavirus outbreak; Virus diseases

Background and aims: Albeit several factors which influence the outcome of corona virus disease (COVID-19) are already known, genetic markers may predict in hospitalized patients still very sparse. Thus, this study, we aimed to analyze whether single-nucleotide polymorphism (SNP) rs5443 gene GNB3 , was associated with higher T cell responses previous studies, might be a suitable biomarker COVID-19 comprehensive German cohort. Methods: We analyzed demographics, pre-existing disorders, laboratory parameters at time hospitalization, genotype cohort (N = 1570) on COVID-19. In sub cohort, SARS-CoV-2-specific genotypes. investigated all fatality multivariable analysis. Results: found younger patient age, normotension or absence diabetes mellitus cardiovascular diseases, normal blood counts, low inflammatory hospital admission were protective against fatal course disease. addition, TT significantly protection (OR: 0.60, 95% CI: 0.40–0.92, p 0.02). also observed increased carriers ( 0.01). Although significant association described previously univariate analysis, only age patients, remained independent predictors Conclusion: Immutable for relatively rare. study could show that SNP is fatality. It as well correlated responses, result milder those patients. Based observations hereby provide further prognostic biomarker, used routine diagnostics predictive factor mortality upon hospitalization.