The host genetics affects gut microbiome diversity in Chinese depressed patients

• DOI: 10.3389/fgene.2022.976814
• Publication Date: 2023-01-09T15:06:58Z
• Authors: Ke Han; Lei Ji; Chenliu Wang; Yang Shao; Changfeng Chen; Liangjie Liu; Mofan Feng; Fengping Yang; Xi Wu; Xingwang Li; Qinglian Xie; Lin He; Yi Shi; Guang He; Zaiquan Dong; Tao Yu
• Keywords: Gut microbiome

The gut microbiome and host genetics are both associated with major depressive disorder (MDD); however, the molecular mechanisms among associations poorly understood, especially in Asian, Chinese group. Our study applied linear discriminant analysis (LDA) effect size (LEfSe) genome-wide association cohort sequencing data genomics data. We reported different microbiota characteristics between MDD control groups group further constructed microbiome. Actinobacteria Pseudomonades were found more significant differences ACE Chao indexes of alpha diversity while no discrepancy beta diversity. three features: rs6108 (p = 8.65 × 10-9), rs77379751 8.56 PWY-5913 rs1775633082 4.54 10-8). A species Romboutsia genus was co-associated Ruminococcus gnavus an internetwork through four genes: METTL8, ITGB2, OTULIN, PROSER3, a strict threshold < 5 10-4). Furthermore, our findings suggested that might affect microRNA expression brain influenced SERPINA5 other spatially close genes afterward. These suggest new linkages depression people, which be mediated by regulation space distance.