A mendelian randomization study investigates the causal relationship between immune cell phenotypes and cerebral aneurysm

• DOI: 10.3389/fgene.2024.1333855
• Publication Date: 2024-01-19T04:27:48Z
• Authors: Xingjie Shi; Tao Wang; Da Teng; Shiqiang Hou; Ning Lin
• Keywords: Mendelian Randomization; Etiology; Genome-wide Association Study; Genetic Association

Background: Cerebral aneurysms (CAs) are a significant cerebrovascular ailment with multifaceted etiology influenced by various factors including heredity and environment. This study aimed to explore the possible link between different types of immune cells occurrence CAs. Methods: We analyzed connection 731 cell signatures risk CAs using publicly available genetic data. The analysis included four features, specifically median brightness levels (MBL), proportionate (PC), definite (DC), morphological attributes (MA). Mendelian randomization (MR) was conducted instrumental variables (IVs) derived from variation linked Results: After multiple test adjustment based on FDR method, inverse variance weighted (IVW) method revealed that 3 phenotypes were These CD45 HLA DR+NK (odds ratio (OR), 1.116; 95% confidence interval (CI), 1.001–1.244; p = 0.0489), CX3CR1 CD14 − CD16 (OR, 0.973; CI, 0.948–0.999; 0.0447). An phenotype CD56 NK found have association in reverse MR 0.950; 0.911–0.990; 0.0156). Conclusion: Our investigation has yielded findings support substantial CAs, thereby suggesting implications for future clinical interventions.