Genetic insights and therapeutic avenues: unraveling the role of polyunsaturated fatty acids as mediators between hypothyroidism and Von Willebrand disease through Mendelian randomization

• DOI: 10.3389/fgene.2024.1426401
• Publication Date: 2025-01-08T06:18:39Z
• Authors: Wenting Zhou; Rui He; Ruwei Ou
• Keywords: Mendelian Randomization; Mendelian inheritance; von Willebrand Disease

Previous observational studies have shown that Hypothyroidism is associated with Von Willebrand Disease (VWD), but the causal relationship has not been confirmed because of conflicting findings and confounding by mixing factors. There are also some suggesting polyunsaturated fatty acids (PUFA) may be one potential mediators. In this study, we used a Mendelian randomization study to analyze between VWD investigate whether mediate effects on VWD. Using large publicly available genome-wide association predominantly European ancestry obtain data Hypothyroidism, VWD, PUFA, conducted two-sample assess role Polyunsaturated in mediating pathway Finally, inferred reverse causality Hypothyroidism. Inverse variance weighting (IVW) was primary analytical method. We found negatively causally development PUFA process (the ratio effect: 24.33%). The remained significant (p < 0.05) after correction each other MVMR. Our unveils novel negative correlation hypothyroidism further enriched discovery partial mediation PUFA. This groundbreaking finding only advances our comprehension etiology opens promising avenues for its control treatment. By elucidating intricate interplay hypothyroidism, research pioneers paradigm shift therapeutic approaches, offering fresh perspectives management complex disorder.