Endogenous Galectin-1 in T Lymphocytes Regulates Anti-prostate Cancer Immunity

• DOI: 10.3389/fimmu.2018.02190
• Publication Date: 2018-09-28T07:27:07Z
• Authors: Enrique Corapi; Gustavo Carrizo; Daniel Compagno; Diego Laderach
• Keywords: Galectin

The identification of effective new therapies for prostate cancer (PCa) requires a better understanding the multiple molecular interactions between tumor cells and their associated microenvironment. In this context, galectin-1 (Gal-1) is key molecule in determination prostatic carcinoma microenviroment; therefore, it essential to understand all processes which protein involved. Most previous studies found literature have focused on microenvironment remodeling properties tumor-secreted Gal-1, through its with glyco-receptors at cell membrane extracellular matrix. This report shows original aspects lectin by focusing role lymphocyte endogenous Gal-1 controlling anti-prostate immunity. Using murine preclinical model cancer, our results demonstrate that lymphocytes modulates proliferative rate cytotoxic function conditions high concentration, mainly derived from cells. such conditions, absence T potentiates anti-tumor immune responses. Further demonstrated CD4+, but CD8+T cells, acts as negative regulator conclusion, tumors require evade lays foundation an immunotherapy strategy cancer.