Strength Exercise Confers Protection in Central Nervous System Autoimmunity by Altering the Gut Microbiota

• DOI: 10.3389/fimmu.2021.628629
• Publication Date: 2021-03-16T04:24:10Z
• Authors: Hao Chen; Liping Shen; Yingying Liu; Xiaomeng Ma; Ling Long; Xueying Ma; Lili Ma; Zhaoyu Chen; Xiuli Lin; Lei Si; Xiaohong Chen
• Keywords: Neuropathology; Intestinal Permeability; Gut–brain axis

Exercise therapy including endurance training and resistance is a promising non-pharmacological in patients with multiple sclerosis (MS). Recent studies have revealed that exercise exerts beneficial impacts on gut microbiota. However, the role of microbiota immune benefits strength (SE; one training) central nervous system (CNS) autoimmunity barely known. Here, we observed 60-min SE ameliorated disease severity neuropathology experimental autoimmune encephalomyelitis (EAE), an animal model MS. increased abundance diversity microbiota, decreased Firmicutes / Bacteroidetes ratio (F/B ratio) intestinal mucosal permeability, enrichment several short-chain fatty acid (SCFA)-producing bacteria. Furthermore, reduced Th17 responses Treg small intestine lymphoid tissues. Compared to control group, microbiota-depleted mice receiving microbiome fecal transplants had lower scores. These results uncovered protective neuroimmunomodulation effects partly via changes microbiome.