Allergic Reactions to Serine Protease-Like Proteins of Staphylococcus aureus

• DOI: 10.3389/fimmu.2021.651060
• Publication Date: 2021-03-23T06:20:34Z
• Authors: Maria Nordengrün; Goran Abdurrahman; Janina Treffon; Hannah Wächter; Barbara C. Kahl; Barbara M. Bröker
• Keywords: Allergic Inflammation

In cystic fibrosis (CF) infectious and allergic airway inflammation cause pulmonary exacerbations that destroy the lungs. Staphylococcus aureus is a common long-term colonizer of recurrent infections in CF. The pathogen also associated with respiratory allergy; especially staphylococcal serine protease-like proteins (Spls) can induce type 2 immune responses humans mice. We measured serum IgE levels specific to 7 proteases S. by ELISA, targeting 5 Spls (76 CF patients 46 controls) staphopains A B (16 controls). Then we compared cytokine release phenotype T cells had been stimulated between controls. strongly increased binding all but not staphopains. Compared healthy controls, their Spl-stimulated released more cytokines (IL-4, IL-5, IL-13) IL-6 no difference secretion 1- or 3 (IFNγ, IL-17A, IL-17F). IL-10 production was low cells. Spl-exposed shifted towards Th2 Th17 profile Th1 Sensitization This discovery could explain episodes hitherto unknown causation extend diagnostic therapeutic portfolio.