Sleep Deprivation Disturbs Immune Surveillance and Promotes the Progression of Hepatocellular Carcinoma

• DOI: 10.3389/fimmu.2021.727959
• Publication Date: 2021-09-04T09:50:17Z
• Authors: Jing Huang; Peiwen Song; Kaibin Hang; Zeka Chen; Zidan Zhu; Yuye Zhang; Jietian Xu; Jie Qin; Binghua Wang; Weimin Qu; Zhili Huang; Chunmin Liang
• Keywords: Immunosuppression; Tumor progression

Sleep disturbance is common in patients with cancer and associated poor prognosis. However, the effects of sleep deprivation (SD) on immune surveillance during development hepatocellular carcinoma (HC) underlying mechanisms are not known. This was investigated present study using mouse models SD tumorigenesis. We determined that acute chronic (CSD) altered relative proportions various cell types blood peripheral organs. CSD increased tumor volume weight, an effect enhanced increasing time. Expression proliferation marker Ki-67 elevated tissues, infiltration into adjacent muscles by CSD. Multicolor flow cytometry analysis revealed significantly reduced numbers antitumor CD3 + T cells natural killer (NK) immunosuppressive CD11b infiltrating microenvironment from spleen via blood. These results indicate impairs promotes immunosuppression to accelerate growth, underscoring importance alleviating HC order prevent progression.