The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Pneumococcal Nasal Colonization and Subsequent Development of Invasive Disease

• DOI: 10.3389/fimmu.2021.732029
• Publication Date: 2021-11-03T07:14:18Z
• Authors: Masamitsu Kono; Denisa Nanushaj; Hideki Sakatani; Daichi Murakami; Masayoshi Hijiya; Tetsuya Kinoshita; Tatsuya Shiga; Fumie Kaneko; Keisuke Enomoto; Gen Sugita; Masayasu Miyajima; Yuka Okada; Shizuya Saika; Muneki Hotomi
• Keywords: TRPV4; Pneumococcal pneumonia

Transient receptor potential (TRP) channels, neuronal stimulations widely known to be associated with thermal responses, pain induction, and osmoregulation, have been shown in recent studies underlying mechanisms inflammatory responses. The role of TRP channels on milieu during bacterial infections has demonstrated. It may vary among types channels/pathogens, however, it is not how function pneumococcal infections. Streptococcus pneumoniae can cause severe such as pneumonia, bacteremia, meningitis, systemic This study examines the (TRPV1 TRPV4) for nasal colonization subsequent development invasive disease a mouse model. Both TRPV1 TRPV4 were related regulation diseases. In particular, influx neutrophils (polymorphonuclear cells) cavity bactericidal activity significantly suppressed knockout mice. lead resulting dissemination bacteria various organs causing high mortality influenza virus coinfection. Regulating host immune responses by could novel strategy against pathogenic microorganisms strong local/systemic inflammation.