Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea

• DOI: 10.3389/fimmu.2021.756550
• Publication Date: 2021-12-01T02:59:50Z
• Authors: Huaxiong Zhang; Yiya Zhang; Yangfan Li; Yaling Wang; Sha Yan; San Xu; Zhili Deng; Xinling Yang; Hongfu Xie; Ji Li
• Keywords: Clinical Pharmacology; Systems pharmacology

Rosacea is significantly associated with dementia, particularly Alzheimer's disease (AD). However, the common underlying molecular mechanism connecting these two diseases remains limited. This study aimed to reveal regulatory networks and identify potential therapeutic drugs for rosacea AD. There were 747 overlapped DEGs (ol-DEGs) that detected in AD rosacea, enriched inflammation-, metabolism-, apoptosis-related pathways. Using TF network analysis, 37 TFs target genes identified as hub genes. They used predict using DGIdb/CMap database. Among 113 predicted drugs, melatonin (MLT) was co-associated both RORA IFN-γ rosacea. Subsequently, pharmacology analysis 19 pharmacological targets of MLT demonstrated could help treating AD/rosacea partly by modulating inflammatory vascular signaling Finally, we verified role on vivo vitro. We found treatment improved rosacea-like skin lesion reducing keratinocyte-mediated cytokine secretion repressing migration HUVEC cells. In conclusion, this contributes pathologies shared an effective strategy via regulating inflammation angiogenesis.