Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid Cells In Vivo

• DOI: 10.3389/fimmu.2021.760198
• Publication Date: 2021-10-29T07:14:49Z
• Authors: Jan-Hendrik Schro...; Luke B. Roberts; Katrin Meissl; Jonathan W. Lo; Dominika Hromadová; Kelly Hayes; Tomasz Zabinski; Emily Read; Catarina Moreira ...; Rita Reis; Jane K. Howard; Richard K. Grencis; Joana F. Neves; Birgit Strobl; Graham M. Lord
• Keywords: Innate lymphoid cell

Innate lymphoid cells (ILC) play a significant role in the intestinal immune response and T-bet + CD127 group 1 (ILC1) have been linked to pathogenesis of human inflammatory bowel disease (IBD). However, functional importance ILC1 context an intact adaptive has controversial. In this report we demonstrate that induced depletion using Rosa26-Cre-ERT2 model resulted loss ILC1, pointing post-developmental requirement expression for these cells. contrast, neither colonic lamina propria (cLP) ILC2 nor cLP ILC3 abundance were altered upon deletion T-bet. Mechanistically, STAT1 or STAT4 are not required development maintenance. Mice with subsequent protected from induction severe colitis vivo . Hence, study provides support clinical IBD treatment based on via targeting its downstream transcriptional targets.