Tuft Cells Increase Following Ovine Intestinal Parasite Infections and Define Evolutionarily Conserved and Divergent Responses

• DOI: 10.3389/fimmu.2021.781108
• Publication Date: 2021-11-22T07:25:08Z
• Authors: Katie A. Hildersley; Tom N. McNeilly; Victoria Gillan; Thomas D. Otto; Stephan Löser; François Gerbe; Philippe Jay; Rick M. Maizels; Eileen Devaney; Collette Britton
• Keywords: Tuft; Teladorsagia circumcincta

Helminth parasite infections of humans and livestock are a global health economic problem. Resistance helminths to current drug treatment is an increasing problem alternative control approaches, including vaccines, needed. Effective vaccine design requires knowledge host immune mechanisms how these stimulated. Mouse models helminth infection indicate that tuft cells, unusual type epithelial cell, may 'sense' in the small intestine trigger 2 response. Currently nothing known cells immunity other species compartments gastrointestinal (GI) tract. Here we address this gap use immunohistochemistry single cell RNA-sequencing detail presence gene expression profile sheep following nematode infections. We identify characterize ovine abomasum (true stomach ruminants) show they increase significantly number with globally important nematodes