Role of CXCL5 in Regulating Chemotaxis of Innate and Adaptive Leukocytes in Infected Lungs Upon Pulmonary Influenza Infection

• DOI: 10.3389/fimmu.2021.785457
• Publication Date: 2021-11-18T09:22:49Z
• Authors: Lei Guo; Nan Li; Zening Yang; Heng Li; Huiwen Zheng; Jinxi Yang; Yanli Chen; Xin Zhao; Junjie Mei; Haijing Shi; G. Scott Worthen; Longding Liu
• Keywords: CXCL5

Respirovirus such as influenza virus infection induces pulmonary anti-viral immune response, orchestration of innate and adaptive immunity restrain viral infection, otherwise causes severe diseases pneumonia. Chemokines regulate leukocyte recruitment to the inflammation site. One chemokine CXCL5, plays a scavenging role host defense against bacterial but its in is underdetermined. Here, using an (H1N1) infected CXCL5 -/- mouse model, we found that not only responds neutrophil infiltration into lungs at stage, also affects B lymphocyte accumulation by regulating expression cell CXCL13. Inhibition CXCL5-CXCR2 axis markedly CXCL13 CD64 + CD44 hi CD274 macrophages/monocytes lungs, vitro administration alveolar macrophages suppresses via upon challenge. deficiency leads increased contributing enhanced response facilitating induced bronchus-associated lymphoid tissue formation during late recovery stages. These data highlight multiple regulatory roles chemotaxis infection.