A Pan-Cancer Analysis of Tumor-Infiltrating B Cell Repertoires

• DOI: 10.3389/fimmu.2021.790119
• Publication Date: 2022-01-05T08:36:45Z
• Authors: Katharine Yu; Akshay Ravoor; Núria Malats; Silvia Pineda; Marina Sirota
• Keywords: Primary tumor

Tumor-infiltrating B cells can play an important role in anti-tumor responses but their presence is not well understood. In this study, we extracted the cell receptor repertoires from 9522 tumor and adjacent non-tumor samples across 28 types Cancer Genome Atlas project performed diversity network analysis. We identified differences statistics subtypes observed a trend towards increased clonality primary tumors compared to tissues. also found significant associations between repertoire features mutation load, stage, age. Our V-gene usage analysis similar patterns colorectal endometrial cancers. Lastly, evaluated prognostic value of with survival seven types. This study warrants further research into better understanding tumor-infiltrating wide range