Monocyte response after colorectal surgery: A prospective cohort study

• DOI: 10.3389/fimmu.2022.1031216
• Publication Date: 2022-10-27T05:12:15Z
• Authors: Pim P. Edomskis; Willem A. Dik; Cloë L. Sparreboom; Nicole M. A. Nagt...; Adrie van Oudenaren; Daniël P. V. Lamb...; Yves Bayon; Noah N. N. van Do...; Anand G. Menon; Eelco J. R. de Graaf; Peter Paul L. O. ...; Johan F. Lange; Pieter J. M. Leenen
• Keywords: Monocyte

Tumor resection is the common approach in patients with colorectal malignancy. Profound insight into inflammatory changes that accompany normal post-operative stress response will establish reference parameters useful for identification of putative complications. Alterations circulating monocytes might be indicative as these cells are considered to most responsive leukocytes trauma. Therefore, aim this study assess monocyte subset kinetic and phenotypic surgery. Fifty undergoing tumor were included a multicenter prospective cohort study. Blood samples collected early morning prior surgery next days through postoperative day three flowcytometric analysis. Leukocyte subtypes identified expression activation stage-related markers by subsets was quantified. Changes leukocyte composition phenotypes prominent at first postoperatively, after which typically returned or near-normal preoperative values. The immunophenotypic alterations notable classical intermediate monocytes. These up-regulation CD64 CD62L, but down-regulation HLA-DR CD54. Markers de-activation, CD163 CD206, consistently increasingly expressed. current gives detailed peripheral blood cancer This form short-term induces rapid significant redistribution immune cells. Immunophenotypic suggest mixed profile cellular de-activation.