Evaluating IL-6 and IL-10 as rapid diagnostic tools for Gram-negative bacteria and as disease severity predictors in pediatric sepsis patients in the intensive care unit

• DOI: 10.3389/fimmu.2022.1043968
• Publication Date: 2022-12-05T06:21:45Z
• Authors: Yunyu Zhang; Biru Li; Botao Ning
• Keywords: Subgroup analysis; Organ dysfunction

Background To explore the diagnostic performance of interleukin (IL)-6 and IL-10 in discriminating Gram bacteria types predicting disease severity intensive care unit (ICU)-hospitalized pediatric sepsis patients. Method We retrospectively collected Th1/Th2 cytokine profiles 146 microbiologically documented Patients were categorized into Gram-positive (G+) or Gram-negative (G-) groups, levels compared. Subgroup analysis was designed to eliminate influence other inflammatory responses on levels. Results After propensity score matching, 78 patients matched according types. Compared with G+ sepsis, IL-6 significantly elevated G- (p < 0.05). Spearman test proved linear correlation between (r = 0.654, p 0.001), their combination indicators (ratio differences) effective identifying sepsis. In subgroup analysis, such elevation significant regardless primary infection site. However, for progressively deteriorating organ function [new progressive multiple dysfunction syndrome (NPMODS)], differences less receiver operating characteristic (ROC) curves group, area under curve (AUC) value 0.679 (95% CI 0.561–0.798) 0.637 0.512–0.762), respectively. The optimal cutoff diagnosing 76.77 pg/ml 18.90 pg/ml, While NPMODS AUC 0.834 0.766–0.902) 0.781 0.701–0.860), Conclusion are comparably G+/G- (PICU) deteriorated observed ICU reveals that complex might have contributed pattern severe patients, therefore confounding efficacy cytokines