Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice

• DOI: 10.3389/fimmu.2022.916618
• Publication Date: 2022-05-19T05:34:20Z
• Authors: Yunping Tang; Qiuyan Pu; Qiaoling Zhao; Yafeng Zhou; Xiaoxia Jiang; Tao Han
• Keywords: Fucoidan; Immunosuppression

The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated this work. Results indicated that LF significantly enhanced the spleen thymus indices, promoted lymphocyte peritoneal macrophages proliferation, increased immune-related cytokines production serum. Moreover, could regulate flora composition, increasing abundance Lactobacillaceae Alistipes , inhibiting Erysipelotrichia Turicibacter Romboutsia Peptostreptococcaceae Faecalibaculum . These results positively correlated with characteristics. Overall, be useful as a new potential strategy to mitigate CTX immunosuppression microbiota disorders.