Effects of Fucoidan Isolated From Laminaria japonica on Immune Response and Gut Microbiota in Cyclophosphamide-Treated Mice
0301 basic medicine
immunosuppression
gut microbiota
Immunology
Immunity
RC581-607
Gastrointestinal Microbiome
3. Good health
Mice
03 medical and health sciences
fucoidan
Polysaccharides
Animals
cyclophosphamide
Immunologic diseases. Allergy
Laminaria
Cyclophosphamide
immunomodulatory
DOI:
10.3389/fimmu.2022.916618
Publication Date:
2022-05-19T05:34:20Z
AUTHORS (6)
ABSTRACT
The effects of Laminaria japonica fucoidan (LF) on immune regulation and intestinal microflora in cyclophosphamide (CTX)-treated mice were investigated in this work. Results indicated that LF significantly enhanced the spleen and thymus indices, promoted spleen lymphocyte and peritoneal macrophages proliferation, and increased the immune-related cytokines production in serum. Moreover, LF could regulate intestinal flora composition, increasing the abundance of Lactobacillaceae and Alistipes, and inhibiting Erysipelotrichia, Turicibacter, Romboutsia, Peptostreptococcaceae, and Faecalibaculum. These results were positively correlated with immune characteristics. Overall, LF could be useful as a new potential strategy to mitigate CTX immunosuppression and intestinal microbiota disorders.
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