Immune-related SERPINA3 as a biomarker involved in diabetic nephropathy renal tubular injury

• DOI: 10.3389/fimmu.2022.979995
• Publication Date: 2022-10-11T07:32:24Z
• Authors: Zuyan Fan; Yan Gao; Nan Jiang; Fengxia Zhang; Shuangxin Liu; Quhuan Li
• Keywords: Renal Injury

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease and has become a serious medical issue globally. Although it known to be associated with glomerular injury, tubular injury been found participate in DN recent years. However, mechanisms diabetic remain unclear. Here, we investigated differentially expressed genes tubules patients by analyzing three RNA-seq datasets downloaded from Gene Expression Omnibus database. set enrichment analysis weighted gene co-expression network showed that highly correlated immune system. The immune-related SERPINA3 was screened out lasso regression Kaplan-Meier survival analyses. Considering an inhibitor mast cell chymase, examined expression level chymase human biopsies upregulated tubules, which consistent results differential analysis. Besides, infiltration degranulation rates cells are augmented DN. By summarizing biological function SERPINA3, based on our those previous studies, speculated protective molecule prevents inhibiting proliferation activation downregulating activity chymase.