Interaction of RARRES1 with ICAM1 modulates macrophages to suppress the progression of kidney renal clear cell carcinoma

• DOI: 10.3389/fimmu.2022.982045
• Publication Date: 2022-10-24T08:15:58Z
• Authors: Xiaodong Geng; Kun Chi; Chao Liu; Zhangning Fu; Xu Wang; Liangliang Meng; Hanfeng Wang; Guangyan Cai; Xiangmei Chen; Quan Hong
• Keywords: 0301 basic medicine; kidney renal clear cell carcinoma; bioinformatic analyses; Macrophages; Immunology; Membrane Proteins; RC581-607; Prognosis; Kidney; Intercellular Adhesion Molecule-1; RARRES1; Kidney Neoplasms; 3. Good health; ICAM1; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Databases, Genetic; Biomarkers, Tumor; Humans; Immunologic diseases. Allergy; Carcinoma, Renal Cell; M1 macrophages

Background RARRES1 is a tumor suppressor protein, and its expression suppressed in various cells. However, whether it participates the immune response kidney renal clear cell carcinoma (KIRC) unknown, defined mechanism not clear. Therefore, of KIRC worthy investigation. Methods We analysed function with The Cancer Genome Atlas (TCGA) database. Kaplan–Meier curve was adopted to estimate survival. RARRES1-correlated genes were obtained from UALCAN database subjected Gene Ontology (GO) enrichment protein–protein interaction (PPI) network analyses. correlation analysis between tumor-infiltrating cells selected performed TIMER also investigated possible by coculturing Caki-1 THP-1 Immunofluorescence assay study difference grade tissues. Results negatively correlated survival patients. GO biological process term most significantly enriched regulation adhesion. ICAM1, which exhibited relatively highest RARRES1, positively infiltration level macrophages. could enhance ICAM1 then induce activation M1 decrease viability apoptosis Conclusion plays an antitumor role promoting inducing offer insights into molecular reveal potential therapeutic target.