A deep look into the storm: Israeli multi-center experience of coronavirus disease 2019 (COVID-19) in patients with autoimmune inflammatory rheumatic diseases before and after vaccinations

• DOI: 10.3389/fimmu.2023.1064839
• Publication Date: 2023-03-13T05:45:50Z
• Authors: Fadi Kharouf; Tali Eviatar; Maya Braun; Elisheva Pokroy-S...; Michal Brodavka; Yair Zloof; Nancy Agmon-Levin; Kochava Toledano; Shirly Oren; Merav Lidar; Devy Zisman; Yonit Tavor; Mirit Amit-Vazina; Firas Sabbah; Gabriel S. Breuer; Amir Dagan; Rima Beshara-Garzuzi; Doron Markovits; Muna Elias; Joy Feld; Oshrat Tayer-Shifman; Tal Gazitt; Tatiana Reitblatt; Limor Rubin; Amir Haddad; Sami Giryes; Daphna Paran; Hagit Peleg; Yair Molad; Ori Elkayam; Dror Mevorach; Alexandra Balbir-...; Yolanda Braun-Mos...
• Keywords: Coronavirus; 2019-20 coronavirus outbreak; Cytokine Storm

Objective We aimed to characterize the course of COVID-19 in autoimmune inflammatory rheumatic disease (AIIRD) patients Israel, taking into consideration several remarkable aspects, including outcomes different outbreaks, effect vaccination campaigns, and AIIRD activity post-recovery. Methods established a national registry diagnosed with COVID-19, demographic data, diagnosis, duration systemic involvement, comorbidities, date clinical course, dates vaccinations. was by positive SARS-CoV-2 polymerase chain reaction. Results Israel experienced 4 outbreaks until 30.11.2021. The first three (1.3.2020 – 30.4.2021) comprised 298 patients. 64.9% had mild 24.2% severe course; 161 (53.3%) were hospitalized, 27 (8.9%) died. th outbreak (delta variant), starting 6 months after beginning campaign 110 Despite similar characteristics, smaller proportion negative as compared 3 regards severity (16 patients,14.5%), hospitalization (29 patients, 26.4%) death (7 6.4%). did not seem influence 1-3 Conclusions is more has an increased mortality active older age comorbidities. Vaccination doses mRNA vaccine against protected from during outbreak. pattern spread general population.