Inflammatory bowel diseases, interleukin-6 and interleukin-6 receptor subunit alpha in causal association with cerebral cortical structure: a Mendelian randomization analysis

• DOI: 10.3389/fimmu.2023.1154746
• Publication Date: 2023-04-20T22:26:03Z
• Authors: Chunlong Liu; Shijie Zhu; Jian Zhang; Kuiwu Ren; Kangkang Li; Jiangtao Yu
• Keywords: Mendelian Randomization; Alpha (finance)

Background Neurological involvement and psychiatric manifestations have been documented in clinical cases of inflammatory bowel disease (IBD); however, the presence a causal relationship remains elusive. The objective this study is to investigate modifications occurring cerebral cortex as result IBD. Methods A compendium data extracted from genome-wide association (GWAS) involving maximum 133,380 European subjects. series Mendelian random analyses were applied exclude heterogeneity pleiotropy, ensuring stability results. Results Neither IBDs nor cytokines (IL-6/IL-6Rα) found significant causality with surface area (SA) thickness (TH) at global level. At regional functional brain level, Crohn’s (CD) significantly decreased TH pars orbitalis (β=-0.003mm, Se=0.001mm, p ivw =4.85×10 -4 ). IL-6 was observed reduce SA middle temporal (β=-28.575mm 2 , Se=6.482mm =1.04×10 -5 ) increase fusiform (β=0.008mm, Se=0.002mm, =8.86×10 opercularis (β=0.009mm, =2.34×10 Furthermore, between IL-6Rα an superior frontal (β=21.132mm Se=5.806mm =2.73×10 supramarginal (β=0.003mm, Se=0.0002mm, =7.86×10 -37 All results passed sensitivity analysis no pleiotropy detected. Conclusion correlation IBD changes cortical structures implies existence gut-brain axis organismal It recommended that patients prioritize long-term management inflammation, level can lead pathologies. Magnetic resonance imaging (MRI) may be considered additional screening option for