Kawasaki disease and the environment: an enigmatic interplay

• DOI: 10.3389/fimmu.2023.1259094
• Publication Date: 2023-12-18T04:53:55Z
• Authors: Ridhima Aggarwal; Rakesh Kumar Pilania; Saniya Sharma; Amit Kumar; Manpreet Dhaliwal; Amit Rawat; Surjit Singh
• Keywords: Etiology; Pathogenesis

Kawasaki disease (KD) is a common systemic vasculitis of childhood. Although it has been almost 6 decades since Dr. Tomisaku reported the first case series KD, underlying cause remains mystery. KD self-limiting disease. However, dreaded complication development coronary artery abnormalities (CAAs). most acquired heart in children developed world and being increasingly from developing countries too. Over years, significant observations have made about epidemiology KD. It usually affects below 5, male preponderance significantly higher incidence North East Asian countries. While several hypotheses proffered for etiology none conclusive. These include associations epidemics Japan United Stated with changes tropospheric wind patterns suggesting wind-borne agents, global studies showing peaks related to season, increased rates populations socioeconomic profile hygiene hypothesis vaccination. Furthermore, self-limiting, febrile nature suggests an infectious etiology, more so sudden decline noted cases onset COVID-19 mitigation measures. Finally, single nucleotide polymorphisms identified as possible risk alleles patients their significance pathogenesis this are also defined. The purpose review elucidate puzzling different environmental factors. Looking at associated may help us better predict understand