Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies

• DOI: 10.3389/fimmu.2023.1269241
• Publication Date: 2023-12-22T04:37:58Z
• Authors: Wenjun Li; Jinze Wu; Yini Zeng; Wen Zheng
• Keywords: Pathophysiology

Epilepsy is a group of enduring neurological disorder characterized by spontaneous and recurrent seizures with heterogeneous etiology, clinical expression, severity, prognosis. Growing body research investigates that epileptic are originated from neuronal synchronized excessive electrical activity. However, the underlying molecular mechanisms epileptogenesis have not yet been fully elucidated 30% patients still resistant to currently available pharmacological treatments throughout life. Over past two decades years accumulated evidences provide strong support hypothesis neuroinflammation, including microglia astrocytes activation, cascade inflammatory mediator releasing, peripheral immune cells infiltration blood into brain, associated epileptogenesis. Meanwhile, an increasing preclinical researches reveal anti-inflammatory therapeutics targeting crucial components effective promising in treatment epilepsy. The aim present study highlight current understanding potential neuroinflammatory therapeutic targets against seizures.