Causal relationship between gut microbiota and kidney diseases: a two-sample Mendelian randomization study

• DOI: 10.3389/fimmu.2023.1277554
• Publication Date: 2024-01-12T04:19:40Z
• Authors: Zhoushan Feng; Yuliang Zhang; Yiyu Lai; Chunhong Jia; Fan Wu; Dunjin Chen
• Keywords: Mendelian Randomization

Background The interplay between gut microbiome genera and inflammatory kidney-related diseases, such as nephrotic syndrome, glomerulonephritis, tubulo-interstitial nephritis, chronic kidney disease, has been observed. However, the causal relationships specific bacterial these renal diseases have not fully elucidated. Objective To investigate potential links different of susceptibility to various conditions utilizing two-sample Mendelian randomization (MR) analyses. Materials methods Genome-wide association study (GWAS) summary statistics microbiota were obtained from published GWASs. Two-sample MR analyses conducted using including inverse-variance weighted (IVW), Egger, others identify microbial conditions. Sensitivity analyses, Cochran’s Q test MR-PRESSO global test, performed validate robustness results detect horizontal pleiotropy. In addition, a reverse analysis was assess causation possibilities. Results By synthesizing insights both primary sensitivity this unveiled critical associations 12 with 7 membranous nephropathy, 3 4 acute 6 disease. Various pinpointed having either positive or negative conditions, evidenced by ranges IVW-OR values (all P< 0.05). congruence bolstered findings, displaying no marked heterogeneity Notably, nephritis exposure did reveal any relationships, thereby strengthening resilience validity associations. Conclusion This explored several risk uncovering These findings enhance our understanding complex they will be beneficial for early diagnosis subsequent treatment.