Extracellular vesicles from adipose stem cells ameliorate allergic rhinitis in mice by immunomodulatory
0301 basic medicine
0303 health sciences
allergic rhinitis
Stem Cells
Immunology
T-Lymphocytes, Helper-Inducer
RC581-607
Immunoglobulin E
Rhinitis, Allergic
anti-inflammation
Mice
Th1 and Th2 cells
Humans
Animals
Cytokines
human adipose tissue-derived stem cells
Female
Immunologic diseases. Allergy
extracellular vesicles
DOI:
10.3389/fimmu.2023.1302336
Publication Date:
2023-12-08T11:58:01Z
AUTHORS (11)
ABSTRACT
Background Human adipose tissue-derived stem cells (hADSCs) exert potent immunosuppressive effects in the allogeneic transplantation treatment. In mouse model of allergic rhinitis (AR), ADSCs partially ameliorated AR. However, no study has evaluated potential therapeutic hADSC-derived extracellular vesicles (hADSC-EVs) on Methods Female BALB/c mice were sensitized and challenged with ovalbumin (OVA) to induce One day after last nasal drop, each group received phosphate buffered saline (PBS) or hADSC-EVs Associated symptoms biological changes then assessed. Results hADSC-EV treatment significantly alleviated symptoms, reduced inflammatory infiltration. Serum levels OVA-specific IgE, interleukin (IL)-4 interferon (IFN)-γ all reduced. The mRNA IL-4 IFN-γ spleen also changed accordingly. T helper (Th)1/Th2 cell ratio increased. efficacy index was higher than that human-derived MSCs published reports MSC ADSC-EVs exhibited a greater most measures when compared our previous involving ADSCs. Conclusion These results demonstrated could ameliorate AR by modulating cytokine secretion Th1/Th2 balance. potentially be viable strategy for Further animal studies are needed elucidate underlying mechanisms optimize clinical protocols.
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