Extracellular matrix remodeling in the tumor immunity

• DOI: 10.3389/fimmu.2023.1340634
• Publication Date: 2024-01-25T04:24:56Z
• Authors: Wei Du; Xueming Xia; Fan Hu; Jiayun Yu
• Keywords: Mechanotransduction; Tumor progression

The extracellular matrix (ECM) is a significant constituent of tumors, fulfilling various essential functions such as providing mechanical support, influencing the microenvironment, and serving reservoir for signaling molecules. abundance degree cross-linking ECM components are critical determinants tissue stiffness. In process tumorigenesis, interaction between immune cells within tumor microenvironment (TME) frequently leads to stiffness, thereby disrupting normal mechanotransduction promoting malignant progression. Therefore, acquiring thorough comprehension dysregulation TME would significantly aid in identification potential therapeutic targets cancer treatment. this regard, we have compiled comprehensive summary encompassing following aspects: (1) principal their roles conditions; (2) intricate TME; (3) pivotal regulators governing onco-immune response ECM.