Effects of Lycium barbarum polysaccharides supplemented to high soybean meal diet on immunity and hepatic health of spotted sea bass Lateolabrax maculatus

• DOI: 10.3389/fimmu.2024.1333469
• Publication Date: 2024-02-06T04:55:55Z
• Authors: Longhui Liu; Yanbo Zhao; Zhangfan Huang; Zhongying Long; Huihui Qin; Hao Lin; Sishun Zhou; Lumin Kong; Jianrong Ma; Zhongbao Li
• Keywords: Lycium; Sea bass

High soybean meal diet (HSBMD) decreased the immunity and damaged liver health of spotted sea bass; in this study, Lycium barbarum polysaccharides (LBP) was added to HSBMD explore its effects on health. The with 44% fish content designed as a blank control. On basis, used replace 50% HSBMD, LBP gradient (1.0, 1.5, 2.0 g/kg) experimental diet. 225-tailed bass initial body weight 44.52 ± 0.24 g were randomly divided into 5 groups fed corresponding for 52 days, respectively. results show that: after ingestion slightly hepatic tissue severely damaged. And addition significantly improved immune capacity protected Specifically, activities serum lysozyme (LZM), immunoglobulin M (IgM), acid phosphatase (ACP) alkaline (AKP) increased, alanine aminotransferase (ALT) aspartate (AST) decreased, morphology improved. In analysis transcriptome results, it found that toll-like receptor 3 (TLR3) (TLR5) down-regulated signaling pathway. may protect by regulating Glycolysis/Gluconeogenesis, Insulin pathway, Steroid biosynthesis other glucolipid-related pathways. conclusion, can improve bass, mechanism be related glucose lipid metabolism.