Exercise intensity governs tumor control in mice with breast cancer

• DOI: 10.3389/fimmu.2024.1339232
• Publication Date: 2024-03-01T04:26:01Z
• Authors: Igor L. Gomes-Santos; Ashwin S. Kumar; Franziska Hausmann; Max N. Meyer; Sarah Z. Shiferaw; Zohreh Amoozgar; Rakesh K. Jain; Dai Fukumura
• Keywords: Intensity; Exercise intensity; Exercise prescription

Introduction Exercise is recommended as an adjunct therapy in cancer, but its effectiveness varies. Our hypothesis that the benefit depends on exercise intensity. Methods We subjected mice to low intensity (Li), moderate (Mi) or high (Hi) exercise, untrained control (Co) groups based their individual maximal running capacity. Results found played a critical role tumor control. Only Mi delayed growth and reduced burden, whereas Li Hi failed exert similar antitumor effects. While both normalized vasculature, only increased infiltrated CD8+ T cells, also displayed enhanced effector function (higher proliferation expression of CD69, INFγ, GzmB). Moreover, induced intensity-dependent mobilization cells into bloodstream. Conclusion These findings shed light intricate relationship between with implications for personalized optimal prescriptions