Aberrant NK cell profile in gestational diabetes mellitus with fetal growth restriction

• DOI: 10.3389/fimmu.2024.1346231
• Publication Date: 2024-02-05T13:39:36Z
• Authors: Yujing Xiong; Yazhen Wang; Mengqi Wu; Shuqiang Chen; Hui Lei; Hui Mu; Haikun Yu; Yongli Hou; Kang Tang; Xutao Chen; Jie Dong; Xiaohong Wang; Lihua Chen
• Keywords: Decidua; Intrauterine growth restriction; Pathogenesis

Gestational diabetes mellitus (GDM) is a gestational disorder characterized by hyperglycemia, that can lead to dysfunction of diverse cells in the body, especially immune cells. It has been reported cells, specifically natural killer (NK) play crucial role normal pregnancy. However, it remains unknown how hyperglycemia affects NK cell thus participates development GDM. In this experiment, GDM mice were induced an intraperitoneal injection streptozotocin (STZ) after pregnancy and found intrauterine growth restriction occurred with STZ-induced GDM, accompanied changed proportion function The percentage cytotoxic CD27 - CD11b + was significantly increased, while nourished reduced decidua mice. Likewise, same trend appeared peripheral blood subsets patients. What’s more, reinfusion mice, fetal alleviated restored. Our findings provide theoretical experimental basis for further exploring pathogenesis