Evaluating the causal association between bronchiectasis and different types of inflammatory bowel disease: a two-sample Mendelian randomization study

• DOI: 10.3389/fimmu.2024.1365108
• Publication Date: 2024-04-04T04:58:00Z
• Authors: Qian Zeng; Da Hu; Yuan Li; Zhiwei Zhou; Jinfeng Wu; Xiaodong Li; Xiqiu Yu
• Keywords: Mendelian Randomization; Genome-wide Association Study; Genetic Association

Background and objectives Previous observational studies have established a connection between bronchiectasis inflammatory bowel disease (IBD), but none of these provided clear explanation for the underlying cause this relationship. The present study thus implemented Mendelian randomization (MR) design to explore possible bidirectional relationships IBD risk, with an additional focus on Crohn’s (CD) ulcerative colitis (UC) as subtypes. Materials methods A large genome-wide association (GWAS)-derived data pool was leveraged examine IBD, CD, UC. Two-sample MR analyses were performed inverse variance weighted (IVW) approach supplemented MR-Egger median methods. Sensitivity used further assess reliability main findings. possibility reverse causation also evaluated using approach. Results IVW analytical revealed that (p = 0.074), UC 0.094), CD 0.644) had no significant impact incidence bronchiectasis, converse being true 0.471, p 0.700, 0.099, respectively). Conclusion This analysis demonstrated higher occurrence in patients is not caused by genetic predisposition.