Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis

• DOI: 10.3389/fimmu.2024.1377236
• Publication Date: 2024-11-21T05:10:11Z
• Authors: Wei Li; Ying Xia; Jing Yang; Arun J. Sanyal; Vijay H. Shah; Naga P. Chalasani; Qigui Yu
• Keywords: Alcoholic Hepatitis

Alcoholic hepatitis (AH) is characterized by intense systemic and liver inflammation, posing significant risks of health complications mortality. While inflammation a crucial defense mechanism against injury infection, its timely resolution essential to prevent tissue damage restore homeostasis. The primarily governed specialized pro-resolving mediators (SPMs), lipid metabolites derived from w-6 w-3 poly-unsaturated fatty acids (PUFAs). Currently, the balance between pro-inflammatory (PLMs) SPMs in PUFA metabolic pathways impact alcohol abstinence on profiles PLMs AH patients are not well studied.