Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer

• DOI: 10.3389/fimmu.2024.1387896
• Publication Date: 2024-04-26T04:33:49Z
• Authors: Jianqing Zheng; Yujie Deng; Bifen Huang; Xiaohui Chen
• Keywords: STK11; Immune status

Background Mutations in STK11 (STK11 Mut ) gene may present a negative impact on survival Non-small Cell Lung Cancer (NSCLC) patients, however, its relationship with immune related genes remains unclear. This study is to unveil whether overexpressed- and mutated-STK11 NSCLC explore (IRGs) are involved mutations. Methods 188 patients intact formalin-fixed paraffin-embedded (FFPE) tissue available for detecting protein expression were included the analysis. After immunohistochemical detection of protein, divided into high group High low Low ), then Kaplan-Meier analysis COX proportional hazards model used compare overall (OS) progression-free (PFS) two groups patients. In addition, mutation data from TCGA database was categorize population, namely Mutated wild-type Wt subgroups. The difference OS between compared. Finally, bioinformatics differences IRGs populations. Results median follow-up time 51.0 months (range 3.0 - 120.0 months) real-life cohort. At end follow-up, 64.36% (121/188) experienced recurrence or metastasis. 64.89% (122/188) ended up cancer-related death. significant protective factor both terms PFS [HR=0.42, 95% CI= (0.29-0.61), P <0.001] [HR=0.36, (0.25, 0.53), <0.001], which consistent finding cohorts [HR=0.76, 95%CI= (0.65, 0.88), <0.001 HR=0.76, <0.001]. cohort, risk lung squamous cell carcinoma (LUSC) adenocarcinoma (LUAD) histology [HR=6.81, (2.16, 21.53), <0.001; HR=1.50, (1.00, 2.26), =0.051, respectively]. Furthermore, 7 IRGs, CALCA, BMP6, S100P, THPO, CGA, PCSK1 MUC5AC, found significantly overexpressed STK11-mutated LUSC LUAD histology. Conclusions at level presence associated poor prognosis NSCLC, mutated might probably alter profiling.