The lysosomal trafficking regulator “LYST”: an 80-year traffic jam

• DOI: 10.3389/fimmu.2024.1404846
• Publication Date: 2024-05-07T04:26:39Z
• Authors: Mackenzie E. Turner; Jingru Che; Gabriel J. M. Mir...; Catherine C. Kennedy; Kevin M. Blum; Sahana Rajesh; Jacob C. Zbinden; Christopher K. Br...; Cameron A. Best; Jenny C. Barker
• Keywords: 0301 basic medicine; 0303 health sciences; Chédiak-Higashi syndrome; Immunology; Vesicular Transport Proteins; wound healing; vesicle traffic; RC581-607; Protein Transport; lysosomes; Mutation; cancer; Humans; Animals; immunotherapy; Immunologic diseases. Allergy; Lysosomes; Chediak-Higashi Syndrome

Lysosomes and lysosome related organelles (LROs) are dynamic at the intersection of various pathways involved in maintaining cellular hemostasis regulating functions. Vesicle trafficking lysosomes LROs critical to maintain their The lysosomal regulator (LYST) is an elusive protein important for regulation membrane dynamics intracellular LROs. Mutations LYST gene result Chédiak-Higashi syndrome, autosomal recessive immunodeficiency characterized by defective granule exocytosis, cytotoxicity, etc. Despite eight decades passing since its initial discovery, a comprehensive understanding LYST’s function biology remains unresolved. Accumulating evidence suggests that dysregulation also manifests other disease states. Here, we review available literature consolidate scientific endeavors relation discuss relevance immunomodulatory therapies, regenerative medicine cancer applications.