Recent advances in understanding the immune microenvironment in ovarian cancer

• DOI: 10.3389/fimmu.2024.1412328
• Publication Date: 2024-06-05T04:23:34Z
• Authors: Jinxin Chen; Lu Yang; Yiming Ma; Ye Zhang
• Keywords: Cancer Immunotherapy; Immune checkpoint; Cancer-Associated Fibroblasts; Peripheral tolerance

The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.