“Dictionary of immune responses” reveals the critical role of monocytes and the core target IRF7 in intervertebral disc degeneration

• DOI: 10.3389/fimmu.2024.1465126
• Publication Date: 2024-10-17T04:37:33Z
• Authors: Peichuan Xu; Kaihui Li; Jinghong Yuan; Jiangminghao Zhao; Huajun Pan; Chongzhi Pan; Wei Xiong; Jianye Tan; Tao Li; Guanfeng Huang; Xiaolong Chen; Xinxin Miao; Dingwen He; Xigao Cheng
• Keywords: IRF7; Cell type

Intervertebral disc degeneration (IDD) is widely regarded as the primary contributor to low back pain(LBP). As an immune-privileged organ, upon onset of IDD, various components nucleus pulposus (NP) are exposed host's immune system, accumulating cytokines. Cytokines facilitate intercellular communication within induce cells polarisation, and exacerbate oxidative stress in IDD.