The future of cell-instructive biomaterials for tissue regeneration–a perspective from early career clinician-scientists

• DOI: 10.3389/fmats.2023.1328904
• Publication Date: 2024-01-16T04:12:03Z
• Authors: Rodrigo Rangel; W. Benton Swanson; David T. Wu
• Keywords: Biomaterial; Regenerative Medicine

Cell-instructive biomaterials are an essential component in tissue engineering and regenerative medicine. In the past three decades since term “Tissue Engineering” was coined, researchers have made significant progress towards regenerating disease or damage tissues organs by combining innovations biomaterials, signaling molecules cell therapies. However, challenges persist including limitations properties of cell-instructive lack advanced manufacturing technologies for precise spatiotemporal control key players engineering, hurdles clinical translation regulatory process. this perspective article, we briefly review current state field evolution our understanding role biomaterial mechanics scaffolding architecture, development self-healing modular such as 3D bioprinting. addition, discuss about how innovation research multi-omics spatial biology, imaging modalities may pave way enhancing cell-biomaterial interactions. Finally, present early career clinicians on potential impact that clinician-scientists can generate development, validation, adoption next-generation application to human health.