Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture
Medicine (General)
0303 health sciences
03 medical and health sciences
R5-920
spontaneous bowel movements
gut microbiota
electroacupuncture
antipsychotic-related constipation
Medicine
16S rRNA gene sequencing
3. Good health
DOI:
10.3389/fmed.2021.737713
Publication Date:
2021-10-14T05:35:10Z
AUTHORS (14)
ABSTRACT
Antipsychotic-related constipation (APRC) is one of the most common side effects taking antipsychotic medication. APRC can seriously impact patient quality life and potentially fatal, though efficacy current treatments low for patients. In this study, we conducted a controlled, pilot randomized, sham-electroacupuncture (SEA) study to assess electroacupuncture (EA) in patients with APRC. We used 16S rRNA gene sequencing microbial profiles these analyze how EA affected their bacteria. Methods: treated 133 randomly assigned or SEA 4 consecutive weeks, fully evaluating 8 weeks after treatment. The participants, outcome assessors, statistics were all blind treatments. Outcomes assessed included changes spontaneous bowel movements (SBMs) frequency rescue measures. detected diversity stool specimens both before treatment using sequencing. Results: Both reduced need measures did not have serious effects. better than at increasing SBMs reducing gut microbiota changed LEfSe analysis indicated genus (belonging phylum Proteobacteria ) following Conclusions: This found that effective safe APRC, could be associated profiles. Further larger sample sizes, needed explore intervention as clinical Trial Registration: ChiCTR, ChiCTR-ONC-17010842, http://www.chictr.org.cn/showproj.aspx?proj=18420 .
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