Microbial Profiles of Patients With Antipsychotic-Related Constipation Treated With Electroacupuncture

• DOI: 10.3389/fmed.2021.737713
• Publication Date: 2021-10-14T05:35:10Z
• Authors: Yuanjia Zheng; Xiumin Jiang; Yacen Gao; Lexin Yuan; Xiaotong Wang; Shengwei Wu; Yucen Xia; Lin Yao; Jinglan Yan; Lanying Liu; Yingdong Wei; Zhiqiang Song; Lin Yu; Yongjun Chen
• Keywords: Medicine (General); 0303 health sciences; 03 medical and health sciences; R5-920; spontaneous bowel movements; gut microbiota; electroacupuncture; antipsychotic-related constipation; Medicine; 16S rRNA gene sequencing; 3. Good health

Antipsychotic-related constipation (APRC) is one of the most common side effects taking antipsychotic medication. APRC can seriously impact patient quality life and potentially fatal, though efficacy current treatments low for patients. In this study, we conducted a controlled, pilot randomized, sham-electroacupuncture (SEA) study to assess electroacupuncture (EA) in patients with APRC. We used 16S rRNA gene sequencing microbial profiles these analyze how EA affected their bacteria. Methods: treated 133 randomly assigned or SEA 4 consecutive weeks, fully evaluating 8 weeks after treatment. The participants, outcome assessors, statistics were all blind treatments. Outcomes assessed included changes spontaneous bowel movements (SBMs) frequency rescue measures. detected diversity stool specimens both before treatment using sequencing. Results: Both reduced need measures did not have serious effects. better than at increasing SBMs reducing gut microbiota changed LEfSe analysis indicated genus (belonging phylum Proteobacteria ) following Conclusions: This found that effective safe APRC, could be associated profiles. Further larger sample sizes, needed explore intervention as clinical Trial Registration: ChiCTR, ChiCTR-ONC-17010842, http://www.chictr.org.cn/showproj.aspx?proj=18420 .