Updating Understanding of Macular Microvascular Abnormalities and Their Correlations With the Characteristics and Progression of Macular Edema or Exudation in Coats' Disease

• DOI: 10.3389/fmed.2022.788001
• Publication Date: 2022-04-13T08:11:22Z
• Authors: Juan Zhang; Lu Ruan; Chen Jiang; Qian Yang; Yuqiao Ju; Qing Chang; Xin Huang
• Keywords: Medicine (General); 03 medical and health sciences; macular edema; macular exudation; R5-920; 0302 clinical medicine; Coats' disease; Medicine; macular microvascular abnormalities; multimodal imaging; optical coherence tomography angiography

To investigate the associations of macular microvascular abnormalities with characteristics and progression edema or exudation in Coats' disease, toward an updated understanding possible risk factors for exudation. Twenty-six eyes (26 patients) disease underwent multimodal imaging were followed 18 months. The classified according to their outcomes (refractory improved). Macular capillary affections assessed by optical coherence tomography angiography (OCTA) fluorescein (FA). Histopathological analysis region additional enucleated eye was performed. OCTA revealed telangiectasia deep plexus (DCP) 76.9% superficial (SCP) 34.6% 26 exceeding rate detected FA (21.4%). Eyes intraretinal cystoid spaces/exudates macula presented higher presence SCP (57.1% vs. 8.3% without, X2 = 6.801, P 0.009) DCP (92.9 58.3% 4.338, 0.037). parafoveal vessel densities (VDs) fractal dimension lower affected than contralateral (all < 0.001). VD (P 0.010) refractory group improved group. Dilated capillaries incomplete walls adjacent inflammatory cells neuroretina histopathological specimen. abnormalities, including loss, positively disease. Intraretinal macula, rather subretinal exudates, may be related telangiectasia. losses